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The title of the lecture should consist of no more than 250 alphabetic letters, and the abstract should be no longer than 1,350 alphabetic letters, including the title. Figures and tables may not be included.
Abstract Sample锛
Ectopic bone formation induced by mechanical stress
Ken-Ichi Furukawa and Shigeru Motomura
Dept. Pharmacol., Hirosaki Univ. Grad. School of Med. Hirosaki 036-8562, Japan
furukawa@cc.hirosaki-u.ac.jp
Ectopic bone formation (EBF) is frequently found in various tissues and affects the prognosis of diseases accompanied by EBF. Although the mechanism of EBF remains unclear, several local factors influencing the progression of EBF has been proposed. We have been focusing on the role of mechanical stress as a local factor in EBF of spinal ligament tissues, i.e., ossification of the posterior longitudinal ligament (OPLL). Comprehensive analyses such as DNA-microarray and differential display RT-PCR have revealed that expressions of several marker genes related to bone formation are enhanced by exposure of ligament cells from OPLL patients to cyclic stretch as a sort of mechanical stress. However, such alteration of gene expressions by cyclic stretch are not observed in ligament cells from non-OPLL patients. These results suggest that ligament cells from OPLL patients have been transformed to be highly sensitive to mechanical stress which induces progression of OPLL. On the basis of these observations, we will discuss a key role of mechanical stress in ectopic bone formation.
锛堝鏈夌枒闂彲鍙傝http://www.pharmacol.or.jp锛
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娆㈣繋骞垮ぇ浼氬憳绉瀬鍙備細锛
涓浗鑽悊瀛︿細
2008骞10鏈23鏃
鍙戦侀偖绠憋細
zhxd@imm.ac.cn
鍙備細淇℃伅琛
濮 鍚
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鎬у埆
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骞撮緞
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鑱岀О
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宸ヤ綔鍗曚綅鍙
閫氳鍦板潃
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閭紪
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鏄惁鎻愪氦
璁烘枃鎽樿
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鈻℃槸
鈻″惁
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鏄惁鍙傚姞
poster浜ゆ祦
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鈻℃槸
鈻″惁
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鏄惁绗竴娆
鍒版棩鏈
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鈻℃槸
鈻″惁
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鎽樿棰樼洰
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鐢 璇
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搴ф満锛
鎵嬫満锛
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